Troy Deeney is a doubt following recent groin surgery, while Christian Kabasele and Craig Cathcart are out.
Liverpool are without Philippe Coutinho, who has a back problem, but captain Jordan Henderson should be fit after recovering from a virus.
Fellow midfielder Adam Lallana faces two months out with a thigh injury.
Daniel Sturridge won’t play on Saturday because of a muscle problem but could return against Hoffenheim on Tuesday.
Expected Starting XI – Watford: Heurelho Gomes, Daryl Janmaat, Younes Kaboul, Miguel Britos, Jose Holebas, Abdoulaye Doucoure, Nathaniel Chalobah, Nordin Amrabat, Tom Cleverley, Roberto Pereyra, Andre Gray
Expected Starting XI – Liverpool: Simon Mignolet, Trent Alexander, Dejan Lovren, Joel Matip, James Milner, Georginio Wijnaldum, Jordan Henderson, Emre Can, Mohammed Sallah, Sadio Mane, Roberto Firmino.
Kick off time: 12:30, Stadium (Venue): Vicarage Road.
Predictions: Watford 1 – 2 Liverpool.